We searched for studies that compared any anti-VEGF combined with vitrectomy versus vitrectomy with no anti-VEGF or with sham treatment or with any other anti-VEGF in people undergoing vitrectomy for the complications of PDR.
frequency of silicone oil tamponade (a tamponade agent used to push the retina towards the eye wall and keep it stable). number of intraoperative retinal breaks (tears in the light sensitive layer of the eye) proportion of people with poor visual acuity (counting fingers or worse) vision-related quality of life measures incidence of revision surgery for recurrent traction/macular pucker (structural alteration in the macula, the part of the eye which is responsible for sharp, central vision, thus causing decline of visual function) in the first six months postoperatively incidence of revision surgery for POVCH in the first six months postoperatively We wanted to find out if the additional use of anti-VEGF agents either before or during diabetic vitrectomy surgery was better than diabetic vitrectomy alone in terms of: We reviewed published research to determine whether anti-VEGF injections around the time of surgery have an effect on the outcomes of vitrectomy for the treatment of complications of PDR. However, there is no clear evidence about the different types of anti-VEGF agents, the best time to use them or their effect on other outcomes. The injection of anti-VEGF agents before vitrectomy for the complications of PDR may make surgery easier, reduce intra- and postoperative bleeding and improve outcomes. Anti-vascular endothelial growth factor agents (anti-VEGFs) are drugs that can stop these abnormal blood vessels growing and control the leaking blood, when they are injected inside the eye.
When this occurs, vitreous loses transparency and the light cannot pass through it, causing vision loss. The most common reason for performing vitrectomy is non-clearing vitreous haemorrhage, where there is bleeding in the inner part of the eye called the vitreous cavity. During this operation, the gel-like substance that exists inside the eye, called the vitreous, is removed. Pars plana vitrectomy is an established surgical treatment for the complications of PDR. It is caused by abnormal new blood vessels that grow on the retina, the light sensitive layer at the back of the eye. Proliferative diabetic retinopathy (PDR) is the most advanced stage of diabetic retinopathy, which is a complication of diabetes.
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